Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 5/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049284 | 0.84 | ADORA2B (0.70) | ADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL3796976 | 0.82 | PTK2 (0.45) | PIK3R1PIK3CAADORA1ADORA2AADORA2B | |
| SCHEMBL3786729 | 0.81 | ADORA2A (0.46) | PIK3R1PIK3CAADORA1ADORA2AADORA2B | |
| SCHEMBL4051487 | 0.79 | PIK3R1 (0.54) | PIK3R1PIK3CAADORA1ADORA2AADORA2B | |
| SCHEMBL3074216 | 0.77 | ADORA1 (0.50) | PIK3R1PIK3CAADORA1ADORA2AADORA2B | |
| SCHEMBL4049370 | 0.77 | ADORA2B (0.47) | PIK3R1PIK3CAADORA1ADORA2AADORA2B | |
| SCHEMBL4051165 | 0.75 | PIK3R1 (0.50) | PIK3R1PIK3CAADORA1ADORA2AADORA2B | |
| SCHEMBL4059301 | 0.75 | ADORA3 (0.49) | PIK3CAADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL3059053 | 0.73 | PIK3R1 (0.52) | PIK3R1PIK3CAADORA1ADORA2AADORA2B | |
| SCHEMBL11368582 | 0.73 | PDE3B (0.55) | PIK3CACDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023763-A1 | Condensed Pyridine Derivatives Useful as A2B Adenosine Receptor Antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-01-22 | — | — | US | claimed |
| US-20090023763-A1 | Condensed Pyridine Derivatives Useful as A2B Adenosine Receptor Antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-01-22 | — | — | US | disclosed |
| US-20090023763-A1 | Condensed Pyridine Derivatives Useful as A2B Adenosine Receptor Antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-01-22 | — | — | US | disclosed |
| US-20090023763-A1 | Condensed Pyridine Derivatives Useful as A2B Adenosine Receptor Antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-01-22 | — | — | US | disclosed |
| EP-1735310-A1 | CONDENSED PYRIDINE DERIVATIVES USEFUL AS A28 ADENOSINE RECEPTOR ANTAGONISTS | Almirall Prodesfarma, S.A. (ES) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005100353-A1 | CONDENSED PYRIDINE DERIVATIVES USEFUL AS A28 ADENOSINE RECEPTOR ANTAGONISTS | ALMIRALL PRODESFARMA, SA (ES) | 2005-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023763-A1 | Condensed Pyridine Derivatives Useful as A2B Adenosine Receptor Antagonists | ADORA2B, ADORA2A, ADORA1 | PIK3R1 1835/4885PIK3CA 1228/4885ADORA1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.