Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11370541 | 0.81 | PDE3B (0.36) | PDE3BPDE3AMAPK14DYRK1APIK3CD | |
| SCHEMBL11363187 | 0.79 | PDE3B (0.42) | PDE3BPDE3AMAPK14DYRK1APIK3CD | |
| SCHEMBL11362214 | 0.77 | PDE3B (0.39) | PDE3BPDE3AMAPK14PIK3CDPIK3CA | |
| SCHEMBL11366056 | 0.77 | PDE3B (0.41) | PDE3BPDE3AMAPK14MAPK1CLK4 | |
| SCHEMBL11375219 | 0.76 | PDE3B (0.41) | PDE3BPDE3AMAPK14MAPK1CLK4 | |
| SCHEMBL3786729 | 0.74 | ADORA2A (0.46) | PDE3BPDE3AMAPK14DYRK1APIK3CD | |
| SCHEMBL3796976 | 0.73 | PTK2 (0.45) | PDE3BPDE3AMAPK14PIK3CDPIK3CA | |
| SCHEMBL4059109 | 0.73 | PIK3R1 (0.55) | PIK3CACDK5CDK5R1 | |
| SCHEMBL4059301 | 0.73 | ADORA3 (0.49) | MAPK14PIK3CACLK4ALDH1A1LMNA | |
| SCHEMBL12256900 | 0.72 | ALDH1A1 (0.34) | PDE3BPDE3AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4276293-A | Compositions and their preparation | STERLING DRUG INC. (US) | 1981-06-30 | — | — | US | disclosed |