Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 12/20 | 0.95 |
| ▸ | CA1 | P00915 | 7/20 | 0.95 |
| ▸ | CA9 | Q16790 | 5/20 | 0.95 |
| ▸ | CA5A | P35218 | 2/20 | 0.95 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.56 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylmethanesulfonamide SCHEMBL7371 | 0.97 | CA2 (1.00) | CA2CA1CA9CA5APRSS1 | |
| Phenylmethanesulfonamide SCHEMBL9006012 | 0.95 | CA2 (0.95) | CA2CA1CA9CA5APRSS1 | |
| Phenylmethanesulfonamide SCHEMBL4428481 | 0.95 | CA2 (0.95) | CA2CA1CA9CA5APRSS1 | |
| Phenylmethanesulfonamide SCHEMBL9400757 | 0.95 | CA2 (0.95) | CA2CA1CA9CA5APRSS1 | |
| Phenylmethanesulfonamide SCHEMBL31442719 | 0.95 | CA2 (0.95) | CA2CA1CA9CA5APRSS1 | |
| Phenylmethanesulfonamide SCHEMBL3638470 | 0.95 | CA2 (0.95) | CA2CA1CA9CA5APRSS1 | |
| Phenylmethanesulfonamide SCHEMBL1546211 | 0.93 | CA2 (0.91) | CA2CA1CA9CA5APRSS1 | |
| Phenylmethanesulfonamide SCHEMBL9492234 | 0.91 | CA2 (0.86) | CA2CA1CA9CA5APRSS1 | |
| Phenylmethanesulfonamide SCHEMBL27420176 | 0.91 | CA2 (0.86) | CA2CA1CA9CA5APRSS1 | |
| Phenylmethanesulfonamide SCHEMBL28388564 | 0.89 | CA2 (0.83) | CA2CA1CA9CA5APRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107162988-B | Process for the manufacture of pyrimidine sulfonamide derivatives | 埃科特莱茵药品有限公司 | 2020-08-21 | — | — | CN | disclosed |
| CN-105992762-A | Process for the manufacture of pyrimidine sulfonamide derivatives | 埃科特莱茵药品有限公司 | 2016-10-05 | — | — | CN | disclosed |
| EP-1322624-B1 | ARYLALKANE-SULFONAMIDES HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | ACTELION PHARMACEUTICALS LTD (CH) | 2009-10-21 | — | — | EP | disclosed |
| US-7091201-B2 | Arylalkane-sulfonamides having endothelin-antagonist activity | ACTELION PHARMACEUTICALS LTD. (CH) | 2006-08-15 | — | — | US | disclosed |
| US-20040102464-A1 | Arylalkane-sulfonamides having endothelin-antagonist activity | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-05-27 | — | — | US | disclosed |
| EP-1322624-A1 | ARYLALKANE-SULFONAMIDES HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | Actelion Pharmaceuticals Ltd. (CH) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024665-A1 | ARYLALKANE-SULFONAMIDES HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | ACTELION PHARMACEUTICALS LTD (CH) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102464-A1 | Arylalkane-sulfonamides having endothelin-antagonist activity | EDNRA, EDNRB, ECE2 | CA2 1259/4885CA1 4830/4885CA9 2676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.