SCHEMBL4059422

SCHEMBL4059422

CO[Si](C)(CCCCN1CCN([Si](C)(C)C)CC1)OC

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CSNK2A2 P19784 2/20 0.33
CSNK2B P67870 2/20 0.33
CSNK2A1 P68400 2/20 0.33
CSNK2A3 Q8NEV1 2/20 0.33
PAOX Q6QHF9 1/20 0.33
USP2 O75604 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
SIGMAR1 Q99720 1/20 0.32
GNAI3 P08754 1/20 0.32
GNAO1 P09471 1/20 0.32
GNAI1 P63096 1/20 0.32
HRH3 Q9Y5N1 1/20 0.31
KCNH2 Q12809 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL128337 0.94 CSNK2A2 (0.34) CSNK2A2CSNK2BCSNK2A1CSNK2A3PAOX
SCHEMBL4062107 0.87 KCNH2 (0.33) CSNK2A2CSNK2BCSNK2A1CSNK2A3PAOX
SCHEMBL4059297 0.87 PAOX (0.36) CSNK2A2CSNK2BCSNK2A1CSNK2A3PAOX
SCHEMBL4058147 0.86
SCHEMBL4070842 0.86 GNAI3 (0.32) CSNK2A2CSNK2BCSNK2A1CSNK2A3PAOX
SCHEMBL11897269 0.86 CSNK2A2 (0.38) CSNK2A2CSNK2BCSNK2A1CSNK2A3PAOX
SCHEMBL4059381 0.85
SCHEMBL4059050 0.85 KCNH2 (0.31) KCNH2
SCHEMBL8083018 0.82 CSNK2A2 (0.43) CSNK2A2CSNK2BCSNK2A1CSNK2A3PAOX
SCHEMBL4060043 0.82 GNAI3 (0.33) PAOXUSP2ALDH1A1HPGDSIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7569691-B2 Protected piperazino group-bearing organoxysilane compound and making method SHIN-ETSU CHEMICAL CO., LTD. (JP) 2009-08-04 US claimed
US-7569691-B2 Protected piperazino group-bearing organoxysilane compound and making method SHIN-ETSU CHEMICAL CO., LTD. (JP) 2009-08-04 US disclosed
EP-1714968-B1 Protected piperazino group-bearing organoxysilane compound and making method SHINETSU CHEMICAL CO (JP) 2008-07-16 EP disclosed
US-20060241294-A1 Protected piperazino group-bearing organoxysilane compound and making method SHIN-ETSU CHEMICAL CO., LTD. 2006-10-26 US disclosed
EP-1714968-A1 Protected piperazino group-bearing organoxysilane compound and making method Shin-Etsu Chemical Co., Ltd. (JP) 2006-10-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060241294-A1 Protected piperazino group-bearing organoxysilane compound and making method PIEZO1, VCL, VIM CSNK2A2 3892/4885CSNK2B 4197/4885CSNK2A1 4178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.