Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCA | P06881 | 3/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.35 |
| ▸ | CTSB | P07858 | 3/20 | 0.35 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.33 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.33 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068934 | 0.82 | CALCA (0.44) | CALCAEGLN1ADAMTS5 | |
| SCHEMBL4059920 | 0.80 | ADORA2A (0.47) | CALCAEGLN1 | |
| SCHEMBL14007368 | 0.63 | EGLN1 (0.59) | CALCAEGLN1 | |
| SCHEMBL14287854 | 0.63 | CALCA (0.42) | CALCAEGLN1CTSB | |
| SCHEMBL4062087 | 0.62 | EGLN1 (0.58) | CALCAEGLN1 | |
| SCHEMBL4063494 | 0.62 | EGLN1 (0.47) | CALCAEGLN1ADAMTS5 | |
| SCHEMBL4066709 | 0.61 | EGLN1 (0.43) | CALCAEGLN1ADAMTS5 | |
| SCHEMBL13993842 | 0.59 | CALCA (0.55) | CALCAEGLN1RPS6KB1 | |
| SCHEMBL4061351 | 0.59 | CALCA (0.55) | CALCAEGLN1RPS6KB1 | |
| SCHEMBL2108266 | 0.59 | ADAMTS5 (0.51) | ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326865-B1 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2009-05-06 | — | — | EP | claimed |