Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 17/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | MARK3 | P27448 | 2/20 | 0.39 |
| ▸ | BRSK2 | Q8IWQ3 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | ULK1 | O75385 | 2/20 | 0.35 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055333 | 0.78 | TBK1 (0.59) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL3389341 | 0.77 | TBK1 (0.40) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL13460158 | 0.73 | TBK1 (0.43) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL3387171 | 0.73 | STK17A (0.42) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL30800587 | 0.73 | TBK1 (0.44) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL27087784 | 0.73 | TBK1 (0.44) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL29989291 | 0.73 | TBK1 (0.43) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL3387252 | 0.72 | ALDH1A1 (0.48) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL3386145 | 0.72 | TBK1 (0.39) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL22648366 | 0.72 | TBK1 (0.39) | TBK1IKBKECDK2MARK3BRSK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009122180-A1 | PYRIMIDINE DERIVATIVES CAPABLE OF INHIBITING ONE OR MORE KINASES | MEDICAL RESEARCH COUNCIL (GB) | 2009-10-08 | — | — | WO | disclosed |