Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL404920 | 0.80 | LMNA (0.61) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL10758855 | 0.80 | GABRA1 (0.49) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL1993247 | 0.78 | GABRA1 (0.67) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL404854 | 0.78 | NR4A2 (0.60) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL1994694 | 0.78 | ALDH1A1 (0.58) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL14357715 | 0.77 | MAPK14 (0.58) | — | |
| SCHEMBL13727294 | 0.77 | LMNA (0.64) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL462496 | 0.75 | NPSR1 (0.47) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL368012 | 0.74 | GABRA1 (0.58) | GABRA1GABRB2GABRA3 | |
| SCHEMBL29790938 | 0.74 | GABRA1 (0.58) | GABRA1GABRB2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125683-A1 | 3-BENZOFURANYL-4-INDOLYL MALEIMIDES AS POTENT GSK3 INHIBITORS FOR NEUROGENERATIVE DISORDERS | The Board of Trustees of the University of Illinois (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077138-A1 | 3-BENZOFURANYL-4-INDOLYL MALEIMIDES AS POTENT GSK3 INHIBITORS FOR NEUROGENERATIVE DISORDERS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-06-26 | — | — | WO | disclosed |