Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNLIP | P16233 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.51 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.51 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071750 | 0.92 | PNLIP (0.55) | PNLIPCYP11B2SGMS2STK39GRM4 | |
| SCHEMBL4073214 | 0.88 | ABL1 (0.46) | PNLIPCYP11B2STK39ABL1SRC | |
| SCHEMBL4062244 | 0.86 | PNLIP (0.60) | PNLIPALDH1A1NPC1ALOX15HTT | |
| SCHEMBL4066166 | 0.84 | ABL1 (0.48) | PNLIPSTK39ABL1SRC | |
| SCHEMBL4065181 | 0.78 | GRM4 (0.57) | PNLIPKMT2ASGMS2STK39MEN1 | |
| SCHEMBL4062656 | 0.78 | PNLIP (0.60) | PNLIPALDH1A1POLBKMT2AKCNK3 | |
| SCHEMBL4240750 | 0.78 | PNLIP (0.56) | PNLIPSGMS2STK39GRM4 | |
| SCHEMBL4069792 | 0.77 | GRM8 (0.53) | PNLIPALDH1A1NPC1RAB9ACYP11B2 | |
| SCHEMBL4060753 | 0.76 | GRM8 (0.52) | PNLIPCYP11B2SGMS2STK39MAPT | |
| SCHEMBL4061920 | 0.75 | ALDH1A1 (0.60) | PNLIPALDH1A1NPC1ALOX15HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |