Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PNLIP | P16233 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073214 | 0.92 | ABL1 (0.46) | ABL1SRCSTK39LMNAPNLIP | |
| SCHEMBL4071750 | 0.88 | PNLIP (0.55) | STK39PNLIP | |
| SCHEMBL4061697 | 0.86 | GRM8 (0.55) | TYK2JAK2JAK1LMNAPNLIP | |
| SCHEMBL4061271 | 0.84 | PNLIP (0.58) | ABL1SRCSTK39PNLIP | |
| SCHEMBL4061218 | 0.79 | GRM8 (0.43) | ABL1SRCTYK2JAK2JAK1 | |
| SCHEMBL4058614 | 0.78 | GRM8 (0.53) | LMNAPNLIP | |
| SCHEMBL8663074 | 0.77 | TAS1R3 (0.44) | — | |
| SCHEMBL4060750 | 0.77 | POLB (0.50) | ABL1SRCTYK2JAK2JAK1 | |
| SCHEMBL4060887 | 0.76 | POLB (0.49) | — | |
| SCHEMBL17244759 | 0.75 | GRM8 (0.51) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |