SCHEMBL4062238

SCHEMBL4062238

O=C(O)c1ccc(OC(F)=C(F)F)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.53
CA1 P00915 3/20 0.52
CA2 P00918 3/20 0.52
TSHR P16473 3/20 0.50
TP53 P04637 1/20 0.50
PARP15 Q460N3 1/20 0.47
PARP10 Q53GL7 1/20 0.47
KMT2A Q03164 1/20 0.47
TPMT P51580 1/20 0.46
SRD5A2 P31213 3/20 0.46
PKM P14618 1/20 0.46
NR4A2 P43354 2/20 0.43
ALDH1A1 P00352 2/20 0.43
RXRA P19793 1/20 0.43
RXRB P28702 1/20 0.43
NR4A1 P22736 1/20 0.43
NR4A3 Q92570 1/20 0.43
CA12 O43570 1/20 0.43
CA3 P07451 1/20 0.43
TYR P14679 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15127545 0.87 RXRA (0.47) HSD17B10CA1CA2TSHRKMT2A
SCHEMBL15127546 0.85 SRD5A2 (0.44) HSD17B10CA1CA2TSHRTP53
SCHEMBL5309873 0.85 ELANE (0.52) KMT2ASRD5A2LMNA
SCHEMBL13422205 0.84 HSD17B10 (0.59) HSD17B10CA1CA2TSHRTP53
SCHEMBL9006787 0.84 XDH (0.51) HSD17B10KMT2ASRD5A2ALDH1A1TYR
SCHEMBL15127535 0.84 HDAC1 (0.48) HSD17B10CA1CA2KMT2ANR4A2
SCHEMBL9006789 0.84 XDH (0.51) HSD17B10KMT2ASRD5A2ALDH1A1TYR
SCHEMBL25191767 0.83 XDH (0.65) KMT2AALDH1A1LMNA
SCHEMBL9006510 0.83 RARG (0.48) HSD17B10TP53ALDH1A1RXRARXRB
SCHEMBL9006501 0.83 RARG (0.48) HSD17B10TP53ALDH1A1RXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3613810-A1 ARTICLES AND COMPOSITIONS COMPRISING HOST POLYMERS AND CHROMOPHORES AND METHODS OF PRODUCING THE SAME General Dynamics Mission Systems, Inc. (US) 2020-02-26 EP disclosed
US-20200048428-A1 ARTICLES AND COMPOSITIONS COMPRISING HOST POLYMERS AND CHROMOPHORES AND METHODS OF PRODUCING THE SAME GENERAL DYNAMICS MISSION SYSTEMS, INC. 2020-02-13 US disclosed
US-8697824-B2 Cross-linkable bi-sulphonyl derivatives and their uses for preparing ion-exchanging membranes HYDRO QUEBEC (CA) 2014-04-15 US disclosed
US-8491815-B1 Omnino nanocomposite crosslinked networks CLEMSON UNIVERSITY RESEARCH FOUNDATION 2013-07-23 US disclosed
US-8343636-B2 Crosslinkable hole-transporting materials for organic light-emitting devices UNIVERSITY OF WASHINGTON (US) 2013-01-01 US disclosed
US-8343636-B2 Crosslinkable hole-transporting materials for organic light-emitting devices UNIVERSITY OF WASHINGTON (US) 2013-01-01 US disclosed
US-8198375-B2 Trifluorovinyl aromatic containing poly(alkyl ether) prepolymers BAUSCH & LOMB INCORPORATED (US) 2012-06-12 US disclosed
US-8198375-B2 Trifluorovinyl aromatic containing poly(alkyl ether) prepolymers BAUSCH & LOMB INCORPORATED (US) 2012-06-12 US disclosed
US-8183325-B2 Mixture of polyoxyalkylene radical, polysiloxane radicals and perfluorocyclobutane radical; medical equipment; contact lenses BAUSCH & LOMB INCORPORATED (US) 2012-05-22 US disclosed
US-8017107-B2 Perfluorocyclobutane crosslinked hydrogels ZIMMER, INC. (US) 2011-09-13 US disclosed
EP-0429618-A1 REACTIVE COMPOUNDS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1991-06-05 EP disclosed
US-5021602-A Monomers for condensation polymers THE DOW CHEMICAL COMPANY (US) 1991-06-04 US disclosed
EP-0428708-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
EP-0428709-A1 REACTIVE COMPOUNDS CONTAINING PERFLUOROVINYL GROUPS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
EP-0428706-A1 PERFLUOROVINYL COMPOUNDS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
WO-1990015044-A2 REACTIVE COMPOUNDS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed
WO-1990015042-A2 REACTIVE COMPOUNDS CONTAINING PERFLUOROVINYL GROUPS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed
WO-1990015043-A2 PERFLUOROVINYL COMPOUNDS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed
WO-1990015082-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed
WO-1990003995-A1 COPOLYMERS CONTAINING POLYBENZOXAZOLE, POLYBENZOTHIAZOLE AND POLYBENZIMIDAZOLE MOIETIES THE DOW CHEMICAL COMPANY (US) 1990-04-19 WO disclosed