Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | STAT5B | P51692 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11663254 | 0.80 | PTGS2 (0.41) | ALDH1A1HSD17B10KDM4EHPGDMAPT | |
| SCHEMBL10639732 | 0.79 | ALDH1A1 (0.37) | ALDH1A1HSD17B10KDM4EHPGDMAPT | |
| SCHEMBL17669198 | 0.79 | ALDH1A1 (0.37) | ALDH1A1HSD17B10KDM4EHPGDMAPT | |
| SCHEMBL4057468 | 0.76 | NPSR1 (0.36) | ALDH1A1KDM4EHPGDMAPTALOX15 | |
| SCHEMBL11620177 | 0.74 | GAA (0.39) | ALDH1A1HSD17B10GAA | |
| SCHEMBL10492500 | 0.72 | ALDH1A1 (0.41) | ALDH1A1HSD17B10KDM4EHPGDMAPT | |
| SCHEMBL14908426 | 0.72 | NPSR1 (0.41) | ALDH1A1HSD17B10KDM4EHPGDMAPT | |
| SCHEMBL10361017 | 0.72 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTGAAL3MBTL1 | |
| SCHEMBL10990974 | 0.71 | ALDH1A1 (0.43) | ALDH1A1HSD17B10KDM4EHPGDMAPT | |
| SCHEMBL4059489 | 0.69 | NPSR1 (0.41) | ALDH1A1KDM4EHPGDMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569570-B2 | Thienopyrimidines, process for preparing the same and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-08-04 | — | — | US | disclosed |
| US-7569570-B2 | Thienopyrimidines, process for preparing the same and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-08-04 | — | — | US | disclosed |
| US-7569570-B2 | Thienopyrimidines, process for preparing the same and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-08-04 | — | — | US | disclosed |
| US-20050222174-A1 | Thienopyrimidines, process for preparing the same and use thereof | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 2005-10-06 | — | — | US | disclosed |
| EP-1479684-A1 | THIENOPYRIMIDINES, PROCESS FOR PREPARING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-4831047-A | Tetrazolyl compounds and insecticidal use thereof | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-16 | — | — | US | disclosed |
| US-4829074-A | INSECTICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-09 | — | — | US | disclosed |
| CN-86102389-A | The preparation and the application thereof of the aralkyl compound that the azoles base replaces | — | 1987-01-21 | — | — | CN | disclosed |
| EP-0194064-A2 | Azolyl substituted aralkyl compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-09-10 | — | — | EP | disclosed |
| EP-0181687-A2 | Tetrazolyl compounds useful as insectides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-05-21 | — | — | EP | disclosed |
| WO-1986002072-A1 | TETRAZOLYL COMPOUNDS USEFUL AS INSECTICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222174-A1 | Thienopyrimidines, process for preparing the same and use thereof | GNRHR, CRH, CYP19A1 | ALDH1A1 2092/4885HSD17B10 1664/4885KDM4E 1786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.