Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 7/20 | 0.63 |
| ▸ | MGMT | P16455 | 6/20 | 0.63 |
| ▸ | CDK1 | P06493 | 3/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.63 |
| ▸ | CDK2 | P24941 | 3/20 | 0.63 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | TPO | P07202 | 1/20 | 0.52 |
| ▸ | EPX | P11678 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059711 | 0.84 | MGMT (0.47) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL4001800 | 0.78 | CDC7 (0.60) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL18049872 | 0.77 | PDE5A (0.65) | PIN1MGMTCDK1CCNB1CCNA2 | |
| 6-O-Benzylguanine SCHEMBL61740 | 0.77 | PIN1 (1.00) | PIN1MGMTCDK1CCNB1CCNA2 | |
| 6-O-Benzylguanine SCHEMBL31517079 | 0.77 | PIN1 (1.00) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL16852229 | 0.76 | MGMT (0.64) | PIN1MGMTCDK1CCNB1CCNA2 | |
| 6-O-Benzylguanine SCHEMBL4631744 | 0.76 | PIN1 (0.97) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL3300895 | 0.74 | PIN1 (0.67) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL3259848 | 0.73 | PIN1 (0.65) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL7458810 | 0.72 | PIN1 (0.64) | PIN1MGMTCDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101062928-B | Process for preparing 2-pyrrolidinyl-1h-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside metabolism | IND RES LTD | 2010-10-06 | — | — | CN | disclosed |
| EP-2077268-A1 | Process for preparing inhibitors of nucleoside metabolism | Industrial Research Limited (NZ) | 2009-07-08 | — | — | EP | disclosed |
| EP-1165564-B1 | PROCESS FOR PREPARING INHIBITORS OF NUCLEOSIDE METABOLISM | IND RES LTD (NZ) | 2009-03-11 | — | — | EP | disclosed |
| US-7405297-B2 | Process for preparing inhibitors of nucleoside metabolism | INDUSTRIAL RESEARCH LIMITED (NZ) | 2008-07-29 | — | — | US | disclosed |
| CN-101062928-A | Process for preparing 2-pyrrolidinyl-1h-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside metabolism | IND RES LTD (NZ) | 2007-10-31 | — | — | CN | disclosed |
| CN-100344630-C | 3H, 5H-pyrrolo [3, 2-d ] pyrimidin-4-one derivatives and process for producing the same | IND RES LTD (NZ) | 2007-10-24 | — | — | CN | disclosed |
| US-20070161667-A1 | Process for preparing inhibitors of nucleoside metabolism | BIOCRYST PHARMACEUTICALS, INC. | 2007-07-12 | — | — | US | disclosed |
| US-7211677-B2 | Process for preparing inhibitors of nucleoside metabolism | INDUSTRIAL RESEARCH LIMITED (NZ) | 2007-05-01 | — | — | US | disclosed |
| US-20060089498-A1 | Process for preparing inhibitors of nucleoside metabolism | BIOCRYST PHARMACEUTICALS, INC. | 2006-04-27 | — | — | US | disclosed |
| US-7022852-B2 | Process for preparing inhibitors of nucleoside metabolism | INDUSTRIAL RESEARCH LIMITED (NZ) | 2006-04-04 | — | — | US | disclosed |
| CN-1727341-A | 3H, 5H-pyrrolo [3, 2-d ] pyrimidin-4-one derivatives and process for producing the same | IND RES LTD (NZ) | 2006-02-01 | — | — | CN | disclosed |
| CN-1196704-C | Process for preparing nucleoside metabolism inhibitor and intermediate compound | IND RES LTD (NZ) | 2005-04-13 | — | — | CN | disclosed |
| US-20040181063-A1 | Process for preparing inhibitors of nucleoside metabolism | BIOCRYST PHARMACEUTICALS, INC. | 2004-09-16 | — | — | US | disclosed |
| US-6693193-B1 | COUPLING AN N- AND O-PROTECTED 2,3-DIHYDROXY-PYRROLIDINE TO THE 2-POSITION AND DEPROTECTING | INDUSTRIAL RESEARCH LIMITED (NZ) | 2004-02-17 | — | — | US | disclosed |
| CN-1370171-A | Process for preparing nucleoside metabolism inhibitors | IND RES LTD (NZ) | 2002-09-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089498-A1 | Process for preparing inhibitors of nucleoside metabolism | UGT1A3, AGL, PNP | PIN1 2492/4885MGMT 2560/4885CDK1 393/4885 |
| US-20040181063-A1 | Process for preparing inhibitors of nucleoside metabolism | XDH, PNP, AGL | PIN1 2649/4885MGMT 3473/4885CDK1 306/4885 |
| US-20070161667-A1 | Process for preparing inhibitors of nucleoside metabolism | PNP, UGT1A3, AGL | PIN1 2011/4885MGMT 2477/4885CDK1 436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.