Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407219 | 0.81 | CYP19A1 (0.44) | CYP19A1ALDH1A1MEN1KMT2ACYP26A1 | |
| SCHEMBL406308 | 0.79 | CYP26A1 (0.37) | CYP19A1MEN1KMT2ACYP26A1CYP2D6 | |
| SCHEMBL407733 | 0.75 | NPC1 (0.40) | CYP19A1ALDH1A1MEN1KMT2ACYP26A1 | |
| SCHEMBL406400 | 0.71 | CYP19A1 (0.52) | CYP19A1ALDH1A1CYP26A1CYP2D6HIF1A | |
| SCHEMBL407218 | 0.68 | CYP19A1 (0.53) | CYP19A1MEN1KMT2ACYP26A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL11203801 | 0.66 | CYP2A6 (0.42) | ALDH1A1MEN1KMT2ACYP2D6HIF1A | |
| SCHEMBL12896041 | 0.63 | CYP2D6 (0.49) | CYP26A1CYP2D6HIF1ALMNASMN1; SMN2 | |
| SCHEMBL406307 | 0.62 | SLC6A2 (0.64) | CYP19A1ALDH1A1CYP26A1CYP2D6HIF1A | |
| SCHEMBL10370955 | 0.61 | CYP2D6 (0.48) | ALDH1A1MEN1KMT2ACYP26A1CYP2D6 | |
| SCHEMBL12086996 | 0.60 | TAS1R3 (0.50) | ALDH1A1MEN1KMT2ACYP26A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285787-B1 | 3-SUBSTITUTED PROPANAMINE COMPOUNDS | SK BIOPHARMACEUTICALS CO LTD (KR) | 2015-08-26 | — | — | EP | claimed |
| EP-2285787-B1 | 3-SUBSTITUTED PROPANAMINE COMPOUNDS | SK BIOPHARMACEUTICALS CO LTD (KR) | 2015-08-26 | — | — | EP | disclosed |
| US-8404730-B2 | 3-substituted propanamine compounds | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2013-03-26 | — | — | US | disclosed |
| US-20120046312-A1 | 3-SUBSTITUTED PROPANAMINE COMPOUNDS | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2012-02-23 | — | — | US | disclosed |
| US-8101642-B2 | 3-substituted propanamine compounds | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2012-01-24 | — | — | US | disclosed |
| EP-2285787-A2 | 3-SUBSTITUTED PROPANAMINE COMPOUNDS | SK Holdings Co., Ltd. (KR) | 2011-02-23 | — | — | EP | disclosed |
| US-20100311789-A1 | 3-Substituted Propanamine Compounds | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2010-12-09 | — | — | US | disclosed |
| WO-2009148290-A2 | 3-SUBSTITUTED PROPANAMINE COMPOUNDS | SK HOLDINGS CO., LTD. (KR) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046312-A1 | 3-SUBSTITUTED PROPANAMINE COMPOUNDS | ADRB3, PNMT, OPRK1 | CYP19A1 3574/4885ALDH1A1 177/4885MEN1 2805/4885 |
| US-20100311789-A1 | 3-Substituted Propanamine Compounds | ADRB3, PNMT, OPRK1 | CYP19A1 3574/4885ALDH1A1 177/4885MEN1 2805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.