Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923471 | 0.75 | CAMKK2 (0.38) | AXLCAMKK2JAK2JAK3PIK3CG | |
| SCHEMBL23727504 | 0.74 | MAP2K1 (0.42) | AXLCAMKK2CDK8JAK2JAK3 | |
| SCHEMBL30136186 | 0.74 | MAP2K1 (0.42) | AXLCAMKK2CDK8JAK2JAK3 | |
| SCHEMBL9923093 | 0.72 | CAMKK2 (0.38) | AXLCAMKK2JAK2JAK3PIK3CG | |
| SCHEMBL9923368 | 0.71 | CAMKK2 (0.39) | AXLCAMKK2JAK2JAK3PIK3CG | |
| SCHEMBL28336849 | 0.68 | CSNK2A1 (0.48) | CAMKK2JAK2JAK3KDM4CDYRK1A | |
| SCHEMBL30585872 | 0.68 | CSNK2A1 (0.48) | CAMKK2JAK2JAK3KDM4CDYRK1A | |
| SCHEMBL23365594 | 0.67 | MAP3K5 (0.44) | CCNCCDK8KDM4C | |
| SCHEMBL30122008 | 0.65 | CSNK2A1 (0.52) | AXLCDK8KDM4CGSK3B | |
| SCHEMBL28994444 | 0.65 | PKM (0.45) | AXLCAMKK2CDK8MAPK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641791-B1 | 3-(GUANIDINOCARBONYL)HETEROCYCLE DERIVATIVES, PREPARATION PROCESS AND INTERMEDIATES OF THIS PROCESS, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-29 | — | — | EP | disclosed |