Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 6/20 | 0.36 |
| ▸ | JAK3 | P52333 | 6/20 | 0.36 |
| ▸ | SGK1 | O00141 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923471 | 0.87 | CAMKK2 (0.38) | CAMKK2MAP3K7TAB1AXLJAK2 | |
| SCHEMBL9923093 | 0.75 | CAMKK2 (0.38) | CAMKK2MAP3K7TAB1AXLJAK2 | |
| SCHEMBL9923305 | 0.73 | AXL (0.43) | AXLJAK2JAK3 | |
| SCHEMBL4064011 | 0.71 | AXL (0.46) | CAMKK2AXLJAK2JAK3PIK3CG | |
| SCHEMBL23727504 | 0.71 | MAP2K1 (0.42) | CAMKK2AXLJAK2JAK3NOTUM | |
| SCHEMBL30136186 | 0.71 | MAP2K1 (0.42) | CAMKK2AXLJAK2JAK3NOTUM | |
| SCHEMBL30735475 | 0.69 | PRKAG1 (0.38) | CAMKK2AXLNOTUMCSNK2A1PRKAB2 | |
| SCHEMBL21705072 | 0.69 | MAP3K7 (0.39) | MAP3K7TAB1JAK2JAK3 | |
| SCHEMBL20758384 | 0.68 | AXL (0.41) | MAP3K7TAB1AXLJAK2JAK3 | |
| SCHEMBL155227 | 0.66 | CHEK1 (0.54) | MAP3K7TAB1JAK2JAK3NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078802-A1 | PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-06-14 | — | — | WO | disclosed |