Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.42 |
| ▸ | GNMT | Q14749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3695466 | 0.82 | ADORA3 (0.46) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL3486506 | 0.81 | ADORA2A (0.49) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL8109955 | 0.79 | ADORA2A (0.64) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL2295172 | 0.79 | ADORA2A (0.65) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL258935 | 0.74 | ADORA3 (0.59) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL5964634 | 0.74 | ADORA2A (0.51) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL1976908 | 0.74 | ADORA2A (0.56) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL1081737 | 0.74 | ADORA2A (0.68) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL5964576 | 0.73 | ADORA3 (0.67) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL5689838 | 0.73 | ADORA3 (0.67) | ADORA3ADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076580-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASES | THOMAS JEFFERSON UNIVERSITY (US) | 2009-06-18 | — | — | WO | disclosed |
| WO-2008058238-A2 | ADENOSINE A1 AND A3 RECEPTOR GENE SEQUENCE VARIATIONS FOR PREDICTING DISEASE OUTCOME AND TREATMENT OUTCOME | THOMAS JEFFERSON UNIVERSITY (US) | 2008-05-15 | — | — | WO | disclosed |