Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | MMP1 | P03956 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 2/20 | 0.56 |
| ▸ | MMP9 | P14780 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.51 |
| ▸ | ITGAV | P06756 | 2/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.50 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22412505 | 0.84 | CYP2C9 (0.49) | HPGDKMT2APOLBALDH1A1ALOX12 | |
| SCHEMBL22412637 | 0.79 | CXCR2 (0.43) | HPGDRAB9ANPC1KMT2APOLB | |
| SCHEMBL4067815 | 0.78 | TGM2 (0.55) | MMP1MMP2MMP9EGFRKMT2A | |
| SCHEMBL26640096 | 0.78 | NPC1 (0.62) | HPGDMMP1MMP2MMP9EGFR | |
| SCHEMBL9712813 | 0.77 | NPC1 (0.67) | HPGDMMP1MMP2MMP9EGFR | |
| SCHEMBL27479697 | 0.75 | NPC1 (0.64) | HPGDMMP1MMP2MMP9EGFR | |
| SCHEMBL6582849 | 0.75 | MAOB (0.43) | HPGDMMP1MMP2MMP9RAB9A | |
| SCHEMBL4064577 | 0.75 | KMT2A (0.64) | HPGDRAB9ANPC1KMT2APOLB | |
| SCHEMBL5176479 | 0.75 | MMP1 (0.71) | HPGDMMP1MMP2MMP9EGFR | |
| SCHEMBL9360564 | 0.75 | MMP1 (0.71) | HPGDMMP1MMP2MMP9EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |