Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061558 | 0.89 | HTR2C (0.50) | KCNK3KCNK9 | |
| SCHEMBL4061450 | 0.88 | P4HTM (0.56) | — | |
| SCHEMBL30392421 | 0.85 | RAB9A (0.46) | KCNK3KCNK9 | |
| SCHEMBL4065333 | 0.81 | HTR2C (0.48) | — | |
| SCHEMBL4060887 | 0.81 | POLB (0.49) | — | |
| SCHEMBL19459590 | 0.79 | PKM (0.60) | KCNK3KCNK9ABL1SRC | |
| SCHEMBL4063740 | 0.79 | HTR2C (0.54) | KCNK3KCNK9 | |
| SCHEMBL4058778 | 0.78 | GAA (0.56) | KCNK3KCNK9 | |
| SCHEMBL4062244 | 0.77 | PNLIP (0.60) | KCNK3KCNK9 | |
| SCHEMBL4065181 | 0.76 | GRM4 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |