Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064531 | 0.81 | EGLN3 (0.61) | EGLN1EGLN3EGLN2 | |
| SCHEMBL3420428 | 0.79 | EGLN3 (0.46) | EGLN1EGLN3MEN1KMT2ANPC1 | |
| SCHEMBL2086548 | 0.77 | HTR3E (0.51) | EGLN1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8244097 | 0.74 | EGLN1 (0.69) | EGLN1MEN1KMT2ANPC1KDM4E | |
| SCHEMBL4991904 | 0.71 | EGLN3 (0.41) | EGLN1EGLN3MEN1KMT2ANPC1 | |
| SCHEMBL8248071 | 0.71 | HIF1A (0.56) | EGLN1EGLN3MEN1KMT2ANPC1 | |
| SCHEMBL5311256 | 0.69 | KDM4E (0.46) | EGLN1MEN1KMT2ANPC1HIF1A | |
| SCHEMBL3422969 | 0.68 | EGLN3 (0.47) | EGLN1EGLN3MEN1KMT2AHIF1A | |
| SCHEMBL4075882 | 0.68 | EGLN1 (0.48) | EGLN1EGLN3EGLN2 | |
| SCHEMBL1585746 | 0.68 | EGLN1 (0.46) | EGLN1EGLN3HIF1AEGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009039323-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | claimed |
| WO-2009039323-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009039323-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |