Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.48 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058167 | 0.78 | EGLN1 (0.39) | EGLN1BBOX1ASPHKDM8 | |
| SCHEMBL13908269 | 0.72 | EGLN1 (0.43) | EGLN1EGLN2FTOEGLN3 | |
| SCHEMBL4064531 | 0.69 | EGLN3 (0.61) | EGLN1EGLN2EGLN3 | |
| SCHEMBL4059048 | 0.69 | EGLN1 (0.41) | EGLN1EGLN3BBOX1ASPHKDM8 | |
| SCHEMBL23702701 | 0.68 | KDM4E (0.35) | — | |
| SCHEMBL4065499 | 0.68 | RPA1 (0.58) | EGLN1EGLN3BBOX1ASPHKDM8 | |
| SCHEMBL4065069 | 0.68 | EGLN1 (0.41) | EGLN1EGLN2EGLN3 | |
| SCHEMBL22996403 | 0.67 | BRD4 (0.33) | — | |
| SCHEMBL12777777 | 0.67 | EGLN1 (0.48) | EGLN1EGLN2FTOEGLN3APEX1 | |
| SCHEMBL822253 | 0.67 | FTO (0.50) | EGLN1EGLN2FTOEGLN3BBOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009039323-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | claimed |
| WO-2009039323-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009039323-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |