Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4241672 | 0.82 | HSD11B1 (0.45) | HSD11B1CES2 | |
| SCHEMBL5507886 | 0.81 | HSD11B1 (0.50) | HSD11B1ENPP2CYP26A1CES2 | |
| SCHEMBL4243004 | 0.79 | HSD11B1 (0.60) | HSD11B1CYP2C9ADRA1AHRH1ENPP2 | |
| SCHEMBL4517638 | 0.79 | HSD11B1 (0.73) | HSD11B1CCR5ALDH1A1SMN1; SMN2 | |
| SCHEMBL3542808 | 0.78 | HSD11B1 (0.84) | HSD11B1ENPP2CYP26A1CES2CCR5 | |
| SCHEMBL3548948 | 0.77 | HSD11B1 (0.74) | HSD11B1 | |
| SCHEMBL5511640 | 0.77 | HSD11B1 (0.45) | HSD11B1CES2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4065125 | 0.76 | HSD11B1 (0.56) | HSD11B1CCR5 | |
| SCHEMBL4698707 | 0.75 | HSD11B1 (0.52) | HSD11B1CYP2C9ADRA1AHRH1CES2 | |
| SCHEMBL2985349 | 0.75 | HSD11B1 (0.48) | HSD11B1CYP2C9ADRA1AHRH1CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016047-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007124337-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |