Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 4/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507886 | 0.90 | HSD11B1 (0.50) | HSD11B1PPARACES2 | |
| SCHEMBL5511644 | 0.85 | PPARA (0.42) | HSD11B1ALDH1A1MAPK1ABCB11CYP1A2 | |
| SCHEMBL2993657 | 0.77 | PPARA (0.44) | HSD11B1ALDH1A1MAPK1ABCB11CYP1A2 | |
| SCHEMBL4065127 | 0.77 | HSD11B1 (0.58) | HSD11B1ALDH1A1CES2SMN1; SMN2 | |
| SCHEMBL5507891 | 0.75 | HSD11B1 (0.43) | HSD11B1CYP1A2CYP3A4TSHRPPARA | |
| SCHEMBL5511643 | 0.71 | FBP1 (0.34) | ALDH1A1ABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL4241672 | 0.70 | HSD11B1 (0.45) | HSD11B1CES2 | |
| SCHEMBL3548392 | 0.70 | HSD11B1 (0.76) | HSD11B1ALDH1A1CYP3A4CES2TP53 | |
| SCHEMBL3548948 | 0.69 | HSD11B1 (0.74) | HSD11B1TSHRLMNATP53 | |
| SCHEMBL3549526 | 0.69 | HSD11B1 (0.69) | HSD11B1ALDH1A1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |