Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 5/20 | 0.43 |
| ▸ | MAOA | P21397 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.31 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8345423 | 0.78 | NFE2L2 (0.50) | NPC1RAB9ANFE2L2TRPA1KIF11 | |
| SCHEMBL5674421 | 0.77 | VCP (0.50) | VCPMAOBMAOANPC1RAB9A | |
| SCHEMBL27793545 | 0.77 | VCP (0.50) | VCPMAOBMAOANPC1RAB9A | |
| SCHEMBL154905 | 0.77 | VCP (0.55) | VCPMAOBMAOANPC1RAB9A | |
| SCHEMBL11127611 | 0.77 | VCP (0.50) | VCPMAOBMAOANPC1RAB9A | |
| SCHEMBL29527566 | 0.77 | VCP (0.55) | VCPMAOBMAOANPC1RAB9A | |
| SCHEMBL38650704 | 0.76 | VCP (0.58) | VCPMAOBMAOANPC1RAB9A | |
| SCHEMBL16510538 | 0.74 | ALDH1A1 (0.39) | MAOBMAOANPC1RAB9ATRPA1 | |
| SCHEMBL14753733 | 0.74 | ALDH1A1 (0.36) | NPC1RAB9ATDP1NFE2L2KIF11 | |
| SCHEMBL2660226 | 0.74 | VCP (0.56) | VCPMAOBMAOANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0048411-B1 | PROCESS FOR PREPARING 3-BROMO-4-FLUORO-BENZALDEHYDE ACETALS, INTERMEDIATES AND THEIR PREPARATION | BAYER AG (DE) | 1986-11-12 | — | — | EP | claimed |
| US-4348538-A | IMINES, GLYOCYLIC ACIDS, BENZOYL CYANIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1982-09-07 | — | — | US | claimed |
| EP-0048411-A2 | Process for preparing 3-bromo-4-fluoro-benzaldehyde acetals, intermediates and their preparation | BAYER AG (DE) | 1982-03-31 | — | — | EP | claimed |
| EP-2035425-A1 | AMINO- IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA. | AstraZeneca AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007145570-A9 | AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | WO | disclosed |
| WO-2007145570-A1 | AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2007-12-21 | — | — | WO | disclosed |
| EP-0048411-B1 | PROCESS FOR PREPARING 3-BROMO-4-FLUORO-BENZALDEHYDE ACETALS, INTERMEDIATES AND THEIR PREPARATION | BAYER AG (DE) | 1986-11-12 | — | — | EP | disclosed |
| US-4348538-A | IMINES, GLYOCYLIC ACIDS, BENZOYL CYANIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1982-09-07 | — | — | US | disclosed |
| US-4348538-A | IMINES, GLYOCYLIC ACIDS, BENZOYL CYANIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1982-09-07 | — | — | US | disclosed |
| EP-0048411-A2 | Process for preparing 3-bromo-4-fluoro-benzaldehyde acetals, intermediates and their preparation | BAYER AG (DE) | 1982-03-31 | — | — | EP | disclosed |
| EP-0048411-A2 | Process for preparing 3-bromo-4-fluoro-benzaldehyde acetals, intermediates and their preparation | BAYER AG (DE) | 1982-03-31 | — | — | EP | disclosed |