Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCR7 | P32248 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064674 | 0.99 | ADORA3 (0.39) | ADORA3SMN1; SMN2CCR7PTPN11ADORA2A | |
| SCHEMBL30716876 | 0.99 | ADORA3 (0.39) | ADORA3SMN1; SMN2CCR7PTPN11ADORA2A | |
| SCHEMBL17595255 | 0.77 | MAP3K5 (0.35) | SMN1; SMN2PTPN11 | |
| SCHEMBL258582 | 0.74 | MAP3K5 (0.37) | — | |
| SCHEMBL17800815 | 0.74 | PDE8B (0.35) | — | |
| SCHEMBL3245634 | 0.73 | PDE8B (0.36) | — | |
| SCHEMBL16145849 | 0.72 | PAK1 (0.47) | ADORA3ADORA2AADORA1 | |
| SCHEMBL756296 | 0.71 | HASPIN (0.33) | SMN1; SMN2 | |
| SCHEMBL4408534 | 0.71 | HSP90AA1 (0.39) | SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL159109 | 0.71 | ADORA2A (0.40) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |