Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 5/20 | 0.35 |
| ▸ | CDK1 | P06493 | 3/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946030 | 0.81 | PAK1 (0.31) | PTPN11 | |
| SCHEMBL4065245 | 0.77 | ADORA3 (0.40) | PTPN11SMN1; SMN2 | |
| SCHEMBL9346521 | 0.76 | MAP3K5 (0.41) | MAP3K5CDK2PIN1SMN1; SMN2 | |
| SCHEMBL30716876 | 0.75 | ADORA3 (0.39) | MAP3K5CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL4064674 | 0.75 | ADORA3 (0.39) | MAP3K5CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL130799 | 0.74 | MAP3K5 (0.56) | MAP3K5CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL7621597 | 0.72 | CHUK (0.50) | CHUK | |
| SCHEMBL2891515 | 0.71 | MAP3K5 (0.37) | MAP3K5CDK2PIN1CHUK | |
| SCHEMBL21755893 | 0.71 | MAP3K5 (0.41) | MAP3K5CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL757120 | 0.71 | MAP3K5 (0.41) | MAP3K5CDK2CDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016038562-A1 | THIOGUANINE DERIVATIVES | MALAYSIAN INSTITUTE OF PHARMACEUTICALS AND NUTRACEUTICALS (MY) | 2016-03-17 | — | — | WO | claimed |
| WO-2016038562-A1 | THIOGUANINE DERIVATIVES | MALAYSIAN INSTITUTE OF PHARMACEUTICALS AND NUTRACEUTICALS (MY) | 2016-03-17 | — | — | WO | disclosed |