SCHEMBL258582

SCHEMBL258582

CSc1nc(N)c2nc[nH]c2n1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAP3K5 Q99683 1/20 0.37
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35
BTK Q06187 1/20 0.34
HSP90AB1 P08238 5/20 0.33
ABCB1 P08183 1/20 0.33
HSP90AA1 P07900 1/20 0.31
PDPK1 O15530 1/20 0.31
GDA Q9Y2T3 1/20 0.31
KDM4E B2RXH2 2/20 0.30
ALDH1A1 P00352 2/20 0.30
GAA P10253 1/20 0.30
MAPT P10636 1/20 0.30
PKM P14618 1/20 0.30
KMT2A Q03164 1/20 0.30
LMNA P02545 1/20 0.30
NUDT1 P36639 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL763254 0.81 MAP3K5 (0.39) MAP3K5CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL4408534 0.81 HSP90AA1 (0.39) ABCB1HSP90AA1PDPK1GDAKDM4E
SCHEMBL756296 0.81 HASPIN (0.33) KDM4EALDH1A1GAAKMT2A
SCHEMBL29386248 0.79 ALDH1A1 (0.41) KDM4EALDH1A1GAAKMT2ALMNA
SCHEMBL639897 0.79 HSP90AB1 (0.39) MAP3K5CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL3962781 0.78 RAB9A (0.43) ALDH1A1
SCHEMBL17372396 0.77 LMNA (0.42) CYP1A2CYP3A4CYP2D6CYP2C19HSP90AB1
SCHEMBL3960621 0.77 SMN1; SMN2 (0.45) KDM4EALDH1A1GAAMAPTKMT2A
SCHEMBL5144923 0.76 KDM4E (0.47) KDM4EALDH1A1GAAMAPTKMT2A
SCHEMBL4068517 0.76 METAP2 (0.38) KDM4EALDH1A1GAAMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4414 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 US claimed
US-20250345406-A1 CHIMERIC PROTEINS IN AUTOIMMUNITY SHATTUCK LABS INC (US) 2025-11-13 US claimed
US-20250325494-A1 COMPOSITION FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACID THEMEDIUM THERAPEUTICS CO., LTD. (CN) 2025-10-23 US claimed
EP-4634380-A1 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION ModernaTX, Inc. (US) 2025-10-22 EP claimed
WO-2025151711-A1 NUCLEIC ACID VACCINES TARGETING METHANOGENS Arkea Bio Corp. (US) 2025-07-17 WO claimed
US-20250188013-A1 LIPID COMPOUND AND USE THEREOF THEMEDIUM THERAPEUTICS CO., LTD. (CN) 2025-06-12 US claimed
WO-2025122721-A1 CHIMERIC PROTEINS AND USES THEREOF SHATTUCK LABS, INC. (US) 2025-06-12 WO claimed
EP-4565692-A2 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION ModernaTX, Inc. (US) 2025-06-11 EP claimed
EP-4554616-A1 COMPOSITIONS AND METHODS FOR REDUCING METHANE EMISSIONS IN RUMINANT POPULATIONS Arkea Bio Corp. (US) 2025-05-21 EP claimed
WO-2025049610-A1 MULTI-ACTION PEPTIDES SHATTUCK LABS, INC. (US) 2025-03-06 WO claimed
WO-1995020597-A1 MODIFIED OLIGONUCLEOTIDES CIBA-GEIGY AG (CH) 1995-08-03 WO claimed
EP-0654037-A1 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1995-05-24 EP claimed
EP-0644196-A1 TTTr as a protecting group in nucleotide synthesis CIBA-GEIGY AG (CH) 1995-03-22 EP claimed
EP-0626387-A1 Nucleosides and oligonucleotides with 2'-ether groups CIBA-GEIGY AG (CH) 1994-11-30 EP claimed
US-5332814-A Process for the preparation of carbacyclic nucleosides, and intermediates CIBA-GEIGY CORPORATION (US) 1994-07-26 US claimed
US-5319080-A Antiviral agents CIBA-GEIGY CORPORATION (US) 1994-06-07 US claimed
WO-1994003467-A2 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1994-02-17 WO claimed
EP-0577558-A2 Carbocyclic nucleosides having bicyclic rings, oligonucleotides therefrom, process for their preparation, their use and intermediates CIBA-GEIGY AG (CH) 1994-01-05 EP claimed
EP-0542681-A1 Process for the preparation of carbocyclic nucleosides and its intermediates CIBA-GEIGY AG (CH) 1993-05-19 EP claimed
EP-0538194-A1 Bicyclic nucleosides, oligonucleotides, their method of preparation and intermediates therein CIBA-GEIGY AG (CH) 1993-04-21 EP claimed