Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.45 |
| ▸ | PDE4A | P27815 | 4/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064155 | 0.94 | HRH3 (0.61) | HRH3KCNH2PDE3APDE4BPDE3B | |
| SCHEMBL9484349 | 0.79 | HRH3 (0.70) | HRH3KCNH2PDE3APDE4BPDE3B | |
| SCHEMBL7291472 | 0.79 | HRH3 (0.70) | HRH3KCNH2PDE3APDE4BPDE3B | |
| SCHEMBL7300116 | 0.78 | HRH3 (0.68) | HRH3KCNH2PDE3APDE4BPDE3B | |
| SCHEMBL1376025 | 0.77 | HRH3 (1.00) | HRH3KCNH2PDE3APDE4BPDE3B | |
| SCHEMBL1376834 | 0.76 | HRH3 (1.00) | HRH3KCNH2PDE3APDE3BGPR119 | |
| SCHEMBL1376796 | 0.76 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL1376792 | 0.76 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL28770567 | 0.76 | CYP3A4 (0.49) | HRH3 | |
| SCHEMBL4065933 | 0.75 | HRH3 (0.63) | HRH3PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | claimed |
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |