Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.63 |
| ▸ | PDE4A | P27815 | 3/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 9/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3611900 | 0.78 | HRH3 (1.00) | HRH3 | |
| SCHEMBL3614602 | 0.75 | HRH3 (1.00) | HRH3 | |
| SCHEMBL4054814 | 0.75 | HRH3 (0.58) | HRH3 | |
| SCHEMBL3614609 | 0.75 | HRH3 (1.00) | HRH3 | |
| SCHEMBL4065277 | 0.75 | HRH3 (0.62) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4055300 | 0.75 | HRH3 (0.61) | HRH3NPY1RTLR7 | |
| SCHEMBL4059363 | 0.74 | HTR3A (0.59) | HRH3NPY1RTLR7 | |
| SCHEMBL28770567 | 0.73 | CYP3A4 (0.49) | HRH3NPY1R | |
| SCHEMBL4056938 | 0.73 | HRH3 (0.44) | HRH3NPY1R | |
| SCHEMBL4060869 | 0.73 | HTR3A (0.60) | HRH3NPY1RTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |