Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 12/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | MERTK | Q12866 | 2/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061207 | 0.97 | NPC1 (0.47) | CHKANPC1RAB9ATP53KDM4E | |
| SCHEMBL4065754 | 0.93 | MEN1 (0.41) | NPC1RAB9ATP53KDM4ECD274 | |
| SCHEMBL4062041 | 0.93 | MEN1 (0.43) | NPC1RAB9A | |
| SCHEMBL4061183 | 0.89 | NPC1 (0.41) | CHKANPC1RAB9ATP53KDM4E | |
| SCHEMBL4069185 | 0.88 | HSP90AA1 (0.42) | KDM4E | |
| SCHEMBL13848453 | 0.88 | KDM4E (0.45) | CHKANPC1RAB9ATP53KDM4E | |
| SCHEMBL4067194 | 0.86 | MEN1 (0.41) | NPC1RAB9AKDM4ECD274 | |
| SCHEMBL13848454 | 0.84 | NPC1 (0.44) | CHKANPC1RAB9ATP53KDM4E | |
| SCHEMBL4068033 | 0.82 | MAPT (0.40) | KDM4E | |
| SCHEMBL13848464 | 0.81 | HSP90AA1 (0.53) | CHKAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066060-A2 | 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE | TOPOTARGET A/S (DK) | 2009-05-28 | — | — | WO | disclosed |