Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065754 | 0.93 | MEN1 (0.41) | HSP90AA1PDK1HSP90B1TRAP1KDM4E | |
| SCHEMBL4062041 | 0.92 | MEN1 (0.43) | HSP90AA1PDK1HSP90B1TRAP1HRH3 | |
| SCHEMBL4061207 | 0.91 | NPC1 (0.47) | HSP90AA1KDM4ELMNAMAPTMAPK1 | |
| SCHEMBL4065747 | 0.88 | CHKA (0.48) | KDM4E | |
| SCHEMBL4059575 | 0.88 | NPC1 (0.48) | — | |
| SCHEMBL4069471 | 0.87 | EGFR (0.43) | KDM4ELMNAMAPTMAPK1 | |
| SCHEMBL13848378 | 0.87 | RAB9A (0.47) | HSP90AA1PDK1HSP90B1TRAP1SMN1; SMN2 | |
| SCHEMBL4067194 | 0.85 | MEN1 (0.41) | KDM4ELMNAMAPK1HRH3 | |
| SCHEMBL4068033 | 0.85 | MAPT (0.40) | KDM4ELMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL4061183 | 0.84 | NPC1 (0.41) | KDM4ELMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066060-A2 | 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE | TOPOTARGET A/S (DK) | 2009-05-28 | — | — | WO | disclosed |