Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062041 | 0.99 | MEN1 (0.43) | MEN1KMT2AHRH3NPC1RAB9A | |
| SCHEMBL4065747 | 0.93 | CHKA (0.48) | NPC1RAB9ATP53KDM4ECD274 | |
| SCHEMBL4069185 | 0.93 | HSP90AA1 (0.42) | HRH3MAPK1LMNAMAPTHSP90AA1 | |
| SCHEMBL4061207 | 0.93 | NPC1 (0.47) | MEN1KMT2ANPC1MAPK1HSD17B10 | |
| SCHEMBL4067194 | 0.92 | MEN1 (0.41) | MEN1KMT2AHRH3NPC1MAPK1 | |
| SCHEMBL4068033 | 0.87 | MAPT (0.40) | MAPK1HSD17B10LMNAMAPTHPGD | |
| SCHEMBL13848385 | 0.86 | TSHR (0.44) | MEN1KMT2AHRH3NPC1RAB9A | |
| SCHEMBL13848084 | 0.86 | TSHR (0.46) | MEN1KMT2AHRH3NPC1RAB9A | |
| SCHEMBL4061183 | 0.85 | NPC1 (0.41) | MEN1KMT2ANPC1MAPK1HSD17B10 | |
| SCHEMBL4373611 | 0.83 | FNTA (0.46) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066060-A2 | 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE | TOPOTARGET A/S (DK) | 2009-05-28 | — | — | WO | disclosed |