Edrophonium

Edrophonium

SCHEMBL4065806

CC[N+](C)(C)c1cccc(O)c1.O=S(=O)(O)O.[Cl-]

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHE

The experimentally established mechanism targets of Edrophonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 7/20 0.83
BLM P54132 1/20 0.83
SMN1; SMN2 Q16637 1/20 0.83
TSHR P16473 3/20 0.80
OPRM1 P35372 1/20 0.80
CHRM2 P08172 2/20 0.38
CHRM1 P11229 2/20 0.38
CHRM3 P20309 2/20 0.38
ALDH1A1 P00352 3/20 0.36
CYP3A4 P08684 2/20 0.36
LMNA P02545 2/20 0.35
HSD17B10 Q99714 2/20 0.35
CA12 O43570 1/20 0.35
CA2 P00918 1/20 0.35
CA5A P35218 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35
CA5B Q9Y2D0 1/20 0.35
HPGD P15428 1/20 0.34
HIF1A Q16665 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Edrophonium SCHEMBL19148596 0.91 ACHE (1.00) ACHEBLMSMN1; SMN2TSHROPRM1
Edrophonium SCHEMBL34789 0.91 ACHE (1.00) ACHEBLMSMN1; SMN2TSHROPRM1
Edrophonium SCHEMBL10893551 0.90 ACHE (0.96) ACHEBLMSMN1; SMN2TSHROPRM1
Edrophonium SCHEMBL8009388 0.89 ACHE (1.00) ACHEBLMSMN1; SMN2TSHROPRM1
Edrophonium SCHEMBL34790 0.89 ACHE (1.00) ACHEBLMSMN1; SMN2TSHROPRM1
Edrophonium SCHEMBL29627074 0.89 ACHE (1.00) ACHEBLMSMN1; SMN2TSHROPRM1
Edrophonium SCHEMBL2462104 0.88 ACHE (1.00) ACHEBLMSMN1; SMN2TSHROPRM1
Edrophonium SCHEMBL10893553 0.88 ACHE (0.96) ACHEBLMSMN1; SMN2TSHROPRM1
SCHEMBL4611923 0.74 ACHE (0.71) ACHEBLMSMN1; SMN2TSHROPRM1
SCHEMBL4611780 0.72 ACHE (0.68) ACHEBLMSMN1; SMN2TSHROPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008116165-A9 METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION NEXT SAFETY INC (US) 2009-06-11 WO claimed
WO-2008116165-A2 METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION NEXT SAFETY, INC. (US) 2008-09-25 WO claimed
US-20080066741-A1 METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION HUNTER, CHARLES ERIC 2008-03-20 US claimed
US-20240123168-A1 PRODUCT DELIVERY DEVICES AND METHODS MUSTAPHA JIHAD A (US) 2024-04-18 US disclosed
EP-4255541-A1 PRODUCT DELIVERY DEVICES AND METHODS Breathe Restore, Inc. (US) 2023-10-11 EP disclosed
US-20230181847-A1 PRODUCT DELIVERY DEVICES AND METHODS BREATHE RESTORE INC (US) 2023-06-15 US disclosed
US-11672929-B2 Product delivery devices and methods BREATHE RESTORE, INC. (US) 2023-06-13 US disclosed
WO-2022118225-A1 PRODUCT DELIVERY DEVICES AND METHODS BREATHE RESTORE, INC. (US) 2022-06-09 WO disclosed
US-20220168516-A1 PRODUCT DELIVERY DEVICES AND METHODS BREATHE RESTORE, INC. 2022-06-02 US disclosed
US-9731012-B2 Laser-actuated therapeutic nanoparticles PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2017-08-15 US disclosed
US-9554989-B2 Silk reservoirs for drug delivery TRUSTEES OF TUFTS COLLEGE (US) 2017-01-31 US disclosed
US-20150065685-A1 LASER-ACTUATED THERAPEUTIC NANOPARTICLES PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2015-03-05 US disclosed
US-20150045764-A1 SILK RESERVOIRS FOR DRUG DELIVERY TRUSTEES OF TUFTS COLLEGE 2015-02-12 US disclosed
EP-2827884-A1 SILK RESERVOIRS FOR DRUG DELIVERY Trustees Of Tufts College (US) 2015-01-28 EP disclosed
WO-2013148158-A1 LASER-ACTUATED THERAPEUTIC NANOPARTICLES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2013-10-03 WO disclosed
WO-2013142119-A1 SILK RESERVOIRS FOR DRUG DELIVERY TRUSTEES OF TUFTS COLLEGE (US) 2013-09-26 WO disclosed
EP-1911481-A2 Methods and systems of delivering medication via inhalation Next Safety, Inc. (US) 2008-04-16 EP disclosed