Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Edrophonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 6/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Edrophonium SCHEMBL29627074 | 1.00 | ACHE (1.00) | ACHETSHROPRM1BLMSMN1; SMN2 | |
| Edrophonium SCHEMBL34790 | 1.00 | ACHE (1.00) | ACHETSHROPRM1BLMSMN1; SMN2 | |
| Edrophonium SCHEMBL34789 | 0.98 | ACHE (1.00) | ACHETSHROPRM1BLMSMN1; SMN2 | |
| Edrophonium SCHEMBL10893553 | 0.98 | ACHE (0.96) | ACHETSHROPRM1BLMSMN1; SMN2 | |
| Edrophonium SCHEMBL19148596 | 0.98 | ACHE (1.00) | ACHETSHROPRM1BLMSMN1; SMN2 | |
| Edrophonium SCHEMBL2462104 | 0.98 | ACHE (1.00) | ACHETSHROPRM1BLMSMN1; SMN2 | |
| Edrophonium SCHEMBL10893551 | 0.96 | ACHE (0.96) | ACHETSHROPRM1BLMSMN1; SMN2 | |
| Edrophonium SCHEMBL4065806 | 0.89 | ACHE (0.83) | ACHETSHROPRM1BLMSMN1; SMN2 | |
| SCHEMBL4611923 | 0.83 | ACHE (0.71) | ACHETSHROPRM1BLMSMN1; SMN2 | |
| SCHEMBL4611780 | 0.81 | ACHE (0.68) | ACHETSHROPRM1BLMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941224-A4 | MULTIVALENT SALTS OF PYRIDOSTIGMINE AND RELATED COMPOUNDS | ICN PHARMACEUTICALS (US) | 2000-01-12 | — | — | EP | disclosed |
| EP-0941224-A1 | MULTIVALENT SALTS OF PYRIDOSTIGMINE AND RELATED COMPOUNDS | ICN Pharmaceuticals, Inc. (US) | 1999-09-15 | — | — | EP | disclosed |
| WO-1998022458-A1 | MULTIVALENT SALTS OF PYRIDOSTIGMINE AND RELATED COMPOUNDS | ICN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | disclosed |