Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 18/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 16/20 | 0.49 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.44 |
| ▸ | L3MBTL4 | Q8NA19 | 2/20 | 0.44 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4060911 | 0.99 | L3MBTL3 (0.48) | L3MBTL3L3MBTL1MBTD1L3MBTL4TP53BP1 | |
| SCHEMBL4029976 | 0.85 | HRH4 (0.52) | L3MBTL1GSK3AGSK3BCDK5CDK5R1 | |
| SCHEMBL4061274 | 0.85 | KDM4E (0.49) | GSK3AGSK3BCDK5CDK5R1 | |
| SCHEMBL4057858 | 0.83 | TLR9 (0.42) | L3MBTL3GSK3AGSK3BCDK5CDK5R1 | |
| Hydrochloric Acid SCHEMBL4060793 | 0.82 | TLR9 (0.41) | L3MBTL3GSK3AGSK3BCDK5CDK5R1 | |
| Fumaric Acid SCHEMBL4059029 | 0.80 | HRH4 (0.47) | L3MBTL1GSK3AGSK3BCDK5CDK5R1 | |
| Fumaric Acid SCHEMBL4059032 | 0.80 | HRH4 (0.47) | L3MBTL1GSK3AGSK3BCDK5CDK5R1 | |
| Fumaric Acid SCHEMBL4059019 | 0.80 | HRH4 (0.47) | L3MBTL1GSK3AGSK3BCDK5CDK5R1 | |
| SCHEMBL4065913 | 0.78 | MAPT (0.51) | GSK3AGSK3BCDK5CDK5R1 | |
| SCHEMBL4065919 | 0.78 | MAPT (0.51) | GSK3AGSK3BCDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-B9 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | claimed |
| US-20090149460-A1 | New Compounds | BERG STEFAN | 2009-06-11 | — | — | US | claimed |
| EP-1492785-B1 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | claimed |
| US-7399780-B2 | 3-Heterocyclyl-indole inhibitors of glycogen synthase kinase-3 | ASTRAZENECA AB (SE) | 2008-07-15 | — | — | US | claimed |
| US-5185386-A | Composition for preventing plaque build-up; solvent, evaporation promoter, polyurethane and fluoropolymer | ESSENTIAL DENTAL SYSTEMS, INC. (US) | 1993-02-09 | — | — | US | claimed |
| US-7538163-B2 | Modification of thermoplastic polymers | MEDTRONIC, INC. (US) | 2009-05-26 | — | — | US | disclosed |
| EP-1758995-A1 | IRREVERSIBLE IMMOBILIZATION OF ENZYMES INTO POLYURETHANE COATINGS | UNIVERSITY OF PITTSBURGH (US) | 2007-03-07 | — | — | EP | disclosed |
| US-20060223955-A1 | Modification of thermoplastic polymers | MEDTRONIC, INC. | 2006-10-05 | — | — | US | disclosed |
| WO-2005118801-A1 | IRREVERSIBLE IMMOBILIZATION OF ENZYMES INTO POLYURETHANE COATINGS | UNIVERSITY OF PITTSBURGH (US) | 2005-12-15 | — | — | WO | disclosed |
| EP-1409663-A2 | IRREVERSIBLE IMMOBILIZATION OF DIISOPROPYLFLUOROPHOPHATASE INTO POLYURETHANE COATINGS | UNIVERSITY OF PITTSBURGH (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003066851-A2 | IRREVERSIBLE IMMOBILIZATION OF DIISOPROPYLFLUOROPHOPHATASE INTO POLYURETHANE COATINGS | UNIVERSITY OF PITTSBURGH (US) | 2003-08-14 | — | — | WO | disclosed |
| EP-0608361-B1 | ROOT CANAL FILLING MATERIAL AND ADHESIVE COMPOSITION | ESSENTIAL DENTAL SYSTEMS INC (US) | 2001-03-14 | — | — | EP | disclosed |
| US-5263861-A | Root canal filling material and adhesive composition | ESSENTIAL DENTAL SYSTEMS, INC. (US) | 1993-11-23 | — | — | US | disclosed |
| US-5236362-A | Inserting thermoset resin in root canal and adhesive material suitable for maintaining polymer in root canal | ESSENTIAL DENTAL SYSTEMS, INC. (US) | 1993-08-17 | — | — | US | disclosed |
| WO-1993010176-A1 | ROOT CANAL FILLING MATERIAL AND ADHESIVE COMPOSITION | ESSENTIAL DENTAL SYSTEMS, INC. (US) | 1993-05-27 | — | — | WO | disclosed |
| US-5185386-A | Composition for preventing plaque build-up; solvent, evaporation promoter, polyurethane and fluoropolymer | ESSENTIAL DENTAL SYSTEMS, INC. (US) | 1993-02-09 | — | — | US | disclosed |
| WO-1992016594-A1 | DENTAL COMPOSITION | ESSENTIAL DENTAL SYSTEMS, INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| EP-0465302-A1 | Precursors of isocyanurate polymers having hydroxyl, urethane, isocyanate or acrylate groups, and process for their preparation | ELF ATOCHEM S.A. (FR) | 1992-01-08 | — | — | EP | disclosed |
| US-4243788-A | UNSATURATED ISOCYANURATE, UNSATURATED SOLVENT | ICI AMERICAS INC. (US) | 1981-01-06 | — | — | US | disclosed |
| US-4159376-A | IMPACT STRENGTH, CORROSION RESISTANCE, CARBAMYLATION | ICI AMERICAS INC. (US) | 1979-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149460-A1 | New Compounds | SDHA, CYP11B2, SERPINB1 | L3MBTL3 4885/4885L3MBTL1 4876/4885MBTD1 4340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.