Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 20/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.53 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4242325 | 0.91 | SLC6A9 (0.70) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL4242321 | 0.91 | SLC6A9 (0.70) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL4827134 | 0.89 | SLC6A9 (0.55) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL4059873 | 0.88 | SLC6A9 (0.59) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL4056678 | 0.85 | SLC6A9 (0.55) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL4060320 | 0.85 | SLC6A9 (0.61) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL1378333 | 0.83 | NPC1 (0.58) | SLC6A9KCNH2 | |
| SCHEMBL4066342 | 0.81 | HTR3A (0.47) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5040980 | 0.81 | SLC6A9 (0.59) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL1378682 | 0.81 | SLC6A9 (0.55) | SLC6A9KCNH2SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101072762-B | Phenyl-piperazin methanone derivatives | HOFFMANN LA ROCHE | 2010-06-23 | — | — | CN | disclosed |
| EP-1828154-B1 | PHENYL-PIPERAZIN METHANONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-04-29 | — | — | EP | disclosed |
| US-7429585-B2 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | HOFFMANN-LA ROCHE (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429585-B2 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | HOFFMANN-LA ROCHE (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429585-B2 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | HOFFMANN-LA ROCHE (US) | 2008-09-30 | — | — | US | disclosed |
| CN-101072762-A | Phenyl-piperazin methanone derivatives | HOFFMANN LA ROCHE (CH) | 2007-11-14 | — | — | CN | disclosed |
| US-20070219207-A1 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | JOLIDON SYNESE | 2007-09-20 | — | — | US | disclosed |
| US-20070219207-A1 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | JOLIDON SYNESE | 2007-09-20 | — | — | US | disclosed |
| US-20070219207-A1 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | JOLIDON SYNESE | 2007-09-20 | — | — | US | disclosed |
| EP-1828154-A1 | PHENYL-PIPERAZIN METHANONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-09-05 | — | — | EP | disclosed |
| US-7241761-B2 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | HOFFMANN-LA ROCHE INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241761-B2 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | HOFFMANN-LA ROCHE INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241761-B2 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | HOFFMANN-LA ROCHE INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-20060128712-A1 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-15 | — | — | US | disclosed |
| WO-2006061135-A1 | PHENYL-PIPERAZIN METHANONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-15 | — | — | WO | disclosed |
| WO-2006061135-A1 | PHENYL-PIPERAZIN METHANONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219207-A1 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | GRIK5, GRM5, GRIN2C | SLC6A9 2292/4885KCNH2 274/4885SLC6A5 379/4885 |
| US-20060128712-A1 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups | HTR5A, NPY5R, GRM5 | SLC6A9 4053/4885KCNH2 228/4885SLC6A5 1333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.