SCHEMBL4065987

SCHEMBL4065987

CCCCCc1sc(C)nc1-c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 1/20 0.51
MAPT P10636 3/20 0.46
ALDH1A1 P00352 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.44
TP53 P04637 2/20 0.44
PTGDR2 Q9Y5Y4 1/20 0.43
GAA P10253 1/20 0.43
NTRK1 P04629 1/20 0.43
HSD11B1 P28845 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
PTGS1 P23219 2/20 0.43
PTGS2 P35354 2/20 0.43
ATP4A P20648 2/20 0.43
ATP4B P51164 2/20 0.43
GCGR P47871 2/20 0.43
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2093403 0.86 PTGDR2 (0.43) GPR84MAPTALDH1A1SMN1; SMN2PTGDR2
SCHEMBL2091991 0.85 PTGDR2 (0.42) GPR84MAPTALDH1A1SMN1; SMN2PTGDR2
SCHEMBL2092404 0.84 PTGDR2 (0.43) MAPTALDH1A1SMN1; SMN2PTGDR2GAA
SCHEMBL1417462 0.82 ALDH1A1 (0.68) GPR84MAPTALDH1A1SMN1; SMN2TP53
SCHEMBL11470347 0.82 ALDH1A1 (0.68) GPR84MAPTALDH1A1SMN1; SMN2TP53
SCHEMBL13002963 0.82 ALDH1A1 (0.67) MAPTALDH1A1PTGDR2NTRK1MEN1
SCHEMBL2090126 0.81 PTGDR2 (0.46) MAPTALDH1A1SMN1; SMN2PTGDR2GAA
SCHEMBL1250021 0.80 GPR84 (0.47) GPR84MAPTALDH1A1SMN1; SMN2TP53
SCHEMBL11994177 0.79 ATP4A (0.58) MAPTALDH1A1PTGDR2KMT2AATP4A
SCHEMBL11994165 0.79 ALDH1A1 (0.47) GPR84MAPTALDH1A1SMN1; SMN2PTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102532162-B 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMA CO LTD 2015-05-27 CN disclosed
CN-100497345-C 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis OTSUKA PHARMA CO LTD (JP) 2009-06-10 CN disclosed
EP-2012775-A1 USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS Solvay Pharmaceuticals GmbH (DE) 2009-01-14 EP disclosed
CN-101255170-A 2,3-dihydroimidazo[2,1-b]oxazole compound OTSUKA PHARMA CO LTD (JP) 2008-09-03 CN disclosed
CN-101172981-A 2,3-dihydroimidazo[2,1-b]oxazole compound OTSUKA PHARMA CO LTD (JP) 2008-05-07 CN disclosed
CN-100366624-C 2, 3-dihydro-6-nitroimidazo [2,1-b ] * azole compounds OTSUKA PHARMA CO LTD (JP) 2008-02-06 CN disclosed
WO-2007125049-A1 USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-08 WO disclosed
CN-1878777-A 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis OTSUKA PHARMA CO LTD (JP) 2006-12-13 CN disclosed
CN-1705670-A 2, 3-dihydro-6-nitroimidazo [2, 1-b ] oxazole compounds OTSUKA PHARMA CO LTD (JP) 2005-12-07 CN disclosed