SCHEMBL4066112

SCHEMBL4066112

O=C(O)c1ccccc1C(=O)N(CCc1ccccc1)CCc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.55
KMT2A Q03164 4/20 0.54
MEN1 O00255 2/20 0.54
NPC1 O15118 1/20 0.54
RAB9A P51151 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
ALDH1A1 P00352 2/20 0.50
ALOX15 P16050 1/20 0.50
TSHR P16473 1/20 0.49
LPAR1 Q92633 2/20 0.48
ABCC1 P33527 1/20 0.48
ALOX5 P09917 1/20 0.47
KDM4E B2RXH2 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
RCE1 Q9Y256 1/20 0.44
HDAC3 O15379 1/20 0.44
MAPK1 P28482 1/20 0.44
ADRA1A P35348 1/20 0.44
HDAC4 P56524 1/20 0.44
SLC6A3 Q01959 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12172745 0.81 TSHR (0.71) KMT2AMEN1TDP1ALDH1A1ALOX15
SCHEMBL21561693 0.81 TP53 (0.58) TP53KMT2AALDH1A1ALOX15TSHR
SCHEMBL29370283 0.81 TSHR (0.71) KMT2AMEN1TDP1ALDH1A1ALOX15
Phthalic Acid SCHEMBL4430760 0.80 ALDH1A1 (0.70) KMT2ANPC1RAB9AALDH1A1ALOX15
SCHEMBL5933377 0.77 TDP1 (0.66) TP53KMT2AMEN1NPC1RAB9A
SCHEMBL1827691 0.76 TP53 (0.60) TP53KMT2AMEN1TDP1ALDH1A1
Phthalic Acid SCHEMBL28192884 0.75 TDP1 (0.70) KMT2ANPC1RAB9ATDP1ALDH1A1
SCHEMBL5933364 0.75 TDP1 (0.63) TP53KMT2AMEN1NPC1RAB9A
Phthalic Acid SCHEMBL3679549 0.74 PLK1 (0.57) KMT2AMEN1ALDH1A1ALOX15TSHR
SCHEMBL6841901 0.74 ALDH1A1 (0.62) KMT2AMEN1NPC1RAB9ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1981831-A2 KIT FOR AUTOMATED RESOLVING AGENT SELECTION AND METHOD THEREOF Vaidya, Niteen A. (US) 2008-10-22 EP claimed
WO-2007092264-A2 KIT FOR AUTOMATED RESOLVING AGENT SELECTION AND METHOD THEREOF VAIDYA NITEEN A (US) 2007-08-16 WO claimed
EP-3189039-A1 NOVEL CRYSTALLINE FORMS OF A BACE INHIBITOR, COMPOSITIONS, AND THEIR USE Merck Sharp & Dohme Corp. (US) 2017-07-12 EP disclosed
WO-2016053767-A1 NOVEL CRYSTALLINE FORMS OF A BACE INHIBITOR, COMPOSITIONS, AND THEIR USE MERCK SHARP & DOHME CORP. (US) 2016-04-07 WO disclosed
WO-2016025364-A1 NOVEL CRYSTALLINE FORMS OF A BACE INHIBITOR, COMPOSITIONS, AND THEIR USE MERCK SHARP & DOHME CORP. (US) 2016-02-18 WO disclosed
WO-2009094457-A2 SUBSTITUTED BENZHYDRYLETHERS AUSPEX PHARMACEUTICALS (US) 2009-07-30 WO disclosed
WO-2008151179-A2 SUBSTITUTED PHENETHYLAMINES AUSPEX PHARMACEUTICALS, INC. (US) 2008-12-11 WO disclosed
EP-1981831-A2 KIT FOR AUTOMATED RESOLVING AGENT SELECTION AND METHOD THEREOF Vaidya, Niteen A. (US) 2008-10-22 EP disclosed
WO-2007092264-A2 KIT FOR AUTOMATED RESOLVING AGENT SELECTION AND METHOD THEREOF VAIDYA NITEEN A (US) 2007-08-16 WO disclosed