Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6183444 | 0.84 | HCAR3 (0.52) | HPGDHCAR3ACSS2 | |
| SCHEMBL2884485 | 0.80 | HCAR3 (0.53) | MAPTPOLBHPGDAHRRAB9A | |
| SCHEMBL1256199 | 0.75 | HCAR3 (0.76) | MAPTPOLBHPGDRAB9AMEN1 | |
| SCHEMBL12349868 | 0.75 | HCAR3 (0.57) | MAPTPOLBHPGDRAB9AMEN1 | |
| SCHEMBL29751355 | 0.74 | HCAR3 (0.55) | MAPTPOLBHPGDRAB9AMEN1 | |
| SCHEMBL31132754 | 0.74 | PDE2A (0.50) | MAPTHPGDRAB9ASMN1; SMN2HCAR3 | |
| SCHEMBL6112673 | 0.74 | NAMPT (0.54) | MAPTPOLBHPGDRAB9AMEN1 | |
| SCHEMBL1644905 | 0.73 | MEN1 (0.61) | MAPTPOLBHPGDAHRRAB9A | |
| SCHEMBL29069383 | 0.73 | MAPT (0.70) | MAPTPOLBHPGDAHRRAB9A | |
| SCHEMBL30767829 | 0.73 | MAPT (0.70) | MAPTPOLBHPGDAHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635702-B2 | Imidazole compounds as transforming growth factor (TGF) inhibitors | PFIZER INC. (US) | 2009-12-22 | — | — | US | disclosed |
| EP-1542990-B1 | NOVEL IMIDAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | PFIZER PROD INC (US) | 2009-06-17 | — | — | EP | disclosed |
| US-20070088037-A1 | NOVEL IMIDAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | PFIZER INC. (US) | 2007-04-19 | — | — | US | disclosed |
| US-7153872-B2 | Imidazole compounds as transforming growth factor (TGF) inhibitors | PFIZER INC. (US) | 2006-12-26 | — | — | US | disclosed |
| EP-1542990-A1 | NOVEL IMIDAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | Pfizer Products Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| US-20040106608-A1 | Novel imidazole compounds as transforming growth factor (TGF) inhibitors | PFIZER INC | 2004-06-03 | — | — | US | disclosed |
| WO-2004026859-A1 | NOVEL IMIDAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106608-A1 | Novel imidazole compounds as transforming growth factor (TGF) inhibitors | SMAD3, TGFBR1, TGFBR2 | MAPT 1415/4885POLB 2328/4885HPGD 973/4885 |
| US-20070088037-A1 | NOVEL IMIDAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | TGFBR1, SMAD3, TGFBR2 | MAPT 1204/4885POLB 2382/4885HPGD 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.