Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | IDH2 | P48735 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19675966 | 0.90 | PRKCZ (0.52) | HTR6IDH2DDB1CRBNSYK | |
| SCHEMBL31357223 | 0.90 | PRKCZ (0.52) | HTR6IDH2DDB1CRBNSYK | |
| SCHEMBL4069931 | 0.90 | DDB1 (0.48) | HTR6DDB1CRBNPLK4KDM4E | |
| SCHEMBL19675712 | 0.84 | DDB1 (0.43) | HTR6IDH2DDB1CRBNPRKCZ | |
| SCHEMBL6557163 | 0.82 | SYK (0.53) | HTR6IDH2SYKKCNH2MAPK3 | |
| SCHEMBL21460320 | 0.82 | HTR6 (0.46) | HTR6IDH2SYKKCNH2MAPK3 | |
| SCHEMBL21460361 | 0.82 | HTR6 (0.46) | HTR6IDH2SYKKCNH2MAPK3 | |
| SCHEMBL6557166 | 0.82 | SYK (0.53) | HTR6IDH2SYKKCNH2MAPK3 | |
| SCHEMBL5392079 | 0.81 | PLK4 (0.56) | HTR6IDH2DDB1CRBNKCNH2 | |
| SCHEMBL21460254 | 0.81 | HTR6 (0.57) | HTR6IDH2SYKPRKCZPRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109605-A2 | 2- [(PHENYLAMINO) -PYRIMIDIN-4YLAMIN0] -CYCLOPENTANE CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF KINASES OF THE CELL CYCLE FOR THE TREATMENT OF CANCER | Boehringer Ingelheim International GmbH (DE) | 2009-10-21 | — | — | EP | disclosed |
| WO-2008077885-A2 | 2- [(PHENYLAMINO) -PYRIMIDIN-4YLAMIN0] -CYCLOPENTANE CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF KINASES OF THE CELL CYCLE FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-07-03 | — | — | WO | disclosed |