Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.53 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | IDH2 | P48735 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557163 | 1.00 | SYK (0.53) | SYKKCNH2MAPK3MAPK1AURKB | |
| Oxalic Acid SCHEMBL9310658 | 0.92 | SYK (0.55) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL9312434 | 0.91 | SYK (0.54) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL8989433 | 0.90 | HTR6 (0.53) | SYKKCNH2MAPK3MAPK1AURKB | |
| Hydrochloric Acid SCHEMBL9876688 | 0.87 | HTR6 (0.53) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL21460303 | 0.83 | KCNH2 (0.43) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL4066935 | 0.82 | HTR6 (0.47) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL19251329 | 0.81 | NPSR1 (0.50) | HPGDALOX12SMN1; SMN2GAAATM | |
| SCHEMBL21460320 | 0.81 | HTR6 (0.46) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL21460361 | 0.81 | HTR6 (0.46) | SYKKCNH2MAPK3MAPK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392651-A1 | HETEROCYCLIC UREAS, THEIR PREPARATION AND THEIR USE AS VANILLOID RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002090326-A1 | HETEROCYCLIC UREAS, THEIR PREPARATION AND THEIR USE AS VANILLOID RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-11-14 | — | — | WO | disclosed |