Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL208481 | 0.90 | SLC6A3 (0.41) | RHEBALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL4067647 | 0.88 | POLB (0.37) | CSF1RALDH1A1PIK3CDBRD4PIK3CA | |
| SCHEMBL209419 | 0.88 | POLB (0.37) | CSF1RALDH1A1PIK3CDBRD4PIK3CA | |
| SCHEMBL207570 | 0.84 | MAP2K4 (0.35) | RHEBALDH1A1MAPTSLC6A3KDM4E | |
| SCHEMBL208452 | 0.80 | PDE4D (0.35) | SLC6A3 | |
| SCHEMBL2999303 | 0.79 | SLC6A3 (0.40) | ALDH1A1HSD17B10SLC6A3SMN1; SMN2MEN1 | |
| SCHEMBL4180949 | 0.79 | BMPR1B (0.43) | HPGDSLC6A3KMT2A | |
| SCHEMBL3453529 | 0.79 | MEN1 (0.34) | RHEBALDH1A1HPGDMAPTWNT3A | |
| SCHEMBL2994149 | 0.78 | ALDH1A1 (0.35) | RHEBALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL2065311 | 0.78 | ALDH1A1 (0.40) | ALDH1A1ALOX15HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016047-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007124337-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |