Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072036 | 0.90 | ADRB1 (0.55) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL1266990 | 0.89 | ADRB1 (0.67) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL29738238 | 0.81 | ADRB1 (0.65) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL29738235 | 0.81 | ADRB1 (0.65) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL11074672 | 0.81 | ADRB1 (0.76) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL28773948 | 0.81 | ADRB1 (0.65) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL4068378 | 0.80 | HTR3E (0.55) | ADRB1MAPTNPC1DRD2ALDH1A1 | |
| SCHEMBL4072947 | 0.79 | KDM4E (0.40) | ADRB1MAPTNPC1KMT2AKDM4E | |
| SCHEMBL4069199 | 0.79 | ADRB1 (0.56) | ADRB1MAPTKCNH2ALDH1A1RAB9A | |
| SCHEMBL23675047 | 0.78 | ADRB1 (0.71) | ADRB1MAPTNPC1KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |
| CN-1538956-A | Spiro compounds | ������ҩ��ʽ���� | 2004-10-20 | — | — | CN | disclosed |