Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 6/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.40 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | GALR1 | P47211 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067558 | 0.91 | GALR2 (0.42) | KDM4ERECQLRXRAGRIN1GRIN2B | |
| SCHEMBL4064747 | 0.90 | KDM4E (0.42) | KDM4ERECQLRXRAGRIN1GRIN2B | |
| SCHEMBL4064662 | 0.82 | ALDH1A1 (0.45) | RXRAGRIN1GRIN2BGALR2DRD1 | |
| SCHEMBL4067230 | 0.79 | ADRB1 (0.58) | KDM4EADRB1KMT2ANPC1MAPT | |
| SCHEMBL17893764 | 0.76 | KDM4E (0.44) | KDM4ERECQLRXRAGRIN1GRIN2B | |
| SCHEMBL5761993 | 0.76 | ADRB1 (0.64) | ADRB1MAPT | |
| Hydrochloric Acid SCHEMBL6501617 | 0.75 | ADRB1 (0.62) | ADRB1MAPT | |
| Hydrochloric Acid SCHEMBL6414607 | 0.75 | ADRB1 (0.62) | ADRB1MAPT | |
| SCHEMBL4072922 | 0.75 | BPTF (0.50) | NOTUMKMT2AMAPT | |
| SCHEMBL4067061 | 0.73 | ALDH1A1 (0.42) | KDM4ERXRAGRIN1GRIN2BGALR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |