Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | PREP | P48147 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068290 | 0.92 | L3MBTL3 (0.36) | CHRM2CHRM1CHRM3CTSBCTSS | |
| SCHEMBL4064598 | 0.87 | USP2 (0.33) | CHRM2CHRM1CHRM3CTSKGPR119 | |
| SCHEMBL346826 | 0.80 | HPGD (0.47) | CHRM2CHRM1CHRM3PREPHRH3 | |
| SCHEMBL11889891 | 0.80 | CYP1A2 (0.41) | — | |
| SCHEMBL4658596 | 0.79 | CHRM2 (0.33) | CHRM2CHRM1CHRM3PREPHRH3 | |
| SCHEMBL16341947 | 0.78 | CHRM1 (0.34) | CHRM2CHRM1CHRM3PREPOPRL1 | |
| SCHEMBL4046200 | 0.78 | L3MBTL3 (0.33) | CHRM2CHRM1CHRM3PREP | |
| SCHEMBL16673574 | 0.78 | SIGMAR1 (0.38) | CHRM2CHRM1CHRM3PREPHRH3 | |
| SCHEMBL4060708 | 0.77 | HRH3 (0.36) | HRH3OPRL1 | |
| SCHEMBL16058261 | 0.76 | HRH3 (0.43) | CHRM2CHRM1CHRM3CTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |
| EP-2520568-A1 | Spirocyclic nitriles as inhibitors of protease | SANOFI (FR) | 2012-11-07 | — | — | EP | disclosed |
| EP-2032535-B1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI SA (FR) | 2012-08-01 | — | — | EP | disclosed |
| EP-2032535-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | disclosed |