Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289578 | 0.81 | DDB1 (0.43) | CYP11B1CYP11B2DDB1CRBN | |
| SCHEMBL4064598 | 0.79 | USP2 (0.33) | — | |
| SCHEMBL17121748 | 0.76 | KDM4E (0.41) | DDB1CRBN | |
| SCHEMBL19032234 | 0.76 | CYP11B2 (0.45) | CYP11B2DDB1CRBN | |
| SCHEMBL11889891 | 0.76 | CYP1A2 (0.41) | — | |
| SCHEMBL4258590 | 0.75 | LMNA (0.40) | CYP11B2DDB1CRBNPDCD1LG2CD274 | |
| SCHEMBL20669341 | 0.75 | DDB1 (0.41) | CYP11B2DDB1CRBN | |
| SCHEMBL24802887 | 0.73 | CYP11B1 (0.36) | CYP11B1CYP11B2OPRM1OPRL1LRRK2 | |
| SCHEMBL14804554 | 0.73 | OPRM1 (0.41) | CYP11B1CYP11B2OPRM1OPRL1LRRK2 | |
| SCHEMBL30328485 | 0.72 | ACACB (0.41) | CYP11B1CYP11B2DDB1CRBNJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |
| EP-2520568-A1 | Spirocyclic nitriles as inhibitors of protease | SANOFI (FR) | 2012-11-07 | — | — | EP | disclosed |
| EP-2032535-B1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI SA (FR) | 2012-08-01 | — | — | EP | disclosed |
| EP-2032535-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | disclosed |