Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.53 |
| ▸ | METAP2 | P50579 | 5/20 | 0.42 |
| ▸ | METAP1 | P53582 | 3/20 | 0.42 |
| ▸ | CCR1 | P32246 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367047 | 0.90 | REN (0.55) | RENMETAP2METAP1CCR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27692376 | 0.89 | REN (0.54) | RENMETAP2METAP1CCR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9876283 | 0.89 | REN (0.54) | RENMETAP2METAP1CCR1ALDH1A1 | |
| SCHEMBL4065186 | 0.88 | REN (0.55) | RENMETAP2METAP1CCR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27673691 | 0.87 | REN (0.54) | RENMETAP2METAP1CCR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7360375 | 0.87 | REN (0.54) | RENMETAP2METAP1CCR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10676905 | 0.87 | REN (0.54) | RENMETAP2METAP1CCR1ALDH1A1 | |
| SCHEMBL4066009 | 0.87 | REN (0.40) | RENMETAP2METAP1CCR1PSEN1 | |
| SCHEMBL9683843 | 0.83 | REN (0.69) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL9684516 | 0.83 | REN (0.69) | RENMETAP2METAP1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | claimed |