Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.36 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1222623 | 0.85 | NCF1 (0.57) | CYP8B1NCF1 | |
| SCHEMBL1222834 | 0.83 | CYP2C19 (0.46) | CYP8B1NCF1ACVR1KCNH2 | |
| SCHEMBL1223241 | 0.81 | CHRNB2 (0.53) | CYP8B1NCF1 | |
| SCHEMBL4068487 | 0.80 | EHMT2 (0.41) | CYP8B1KCNH2EHMT2EHMT1 | |
| SCHEMBL4069340 | 0.80 | KCNH2 (0.42) | KCNH2EHMT2EHMT1 | |
| SCHEMBL1224035 | 0.80 | CYP2C19 (0.43) | CYP8B1NCF1ACVR1KCNH2 | |
| SCHEMBL1222688 | 0.78 | CYP2C19 (0.54) | CYP8B1ACVR1KCNH2 | |
| SCHEMBL3634872 | 0.78 | CYP2C19 (0.54) | CYP8B1ACVR1KCNH2 | |
| SCHEMBL3636416 | 0.78 | CYP2C19 (0.54) | CYP8B1ACVR1KCNH2 | |
| SCHEMBL3168429 | 0.78 | CYP8B1 (0.50) | CYP8B1ACVR1KCNH2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605938-B1 | Antibacterial derivatives of napthydrin and quinoline | GLAXO GROUP LTD (GB) | 2009-02-11 | — | — | EP | claimed |
| EP-1605938-A4 | ANTIBACTERIAL AGENTS | GLAXO GROUP LTD (GB) | 2006-11-22 | — | — | EP | claimed |
| EP-1605938-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2005-12-21 | — | — | EP | claimed |
| WO-2004087145-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2004-10-14 | — | — | WO | claimed |