Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | LIPE | Q05469 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | PAM | P19021 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL406877 | 0.84 | KMT2A (0.52) | L3MBTL1ALDH1A1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL463200 | 0.81 | KMT2A (0.44) | L3MBTL1ALDH1A1KMT2AHPGDLIPE | |
| SCHEMBL11323517 | 0.80 | ALDH1A1 (0.47) | MAPK1L3MBTL1ALDH1A1KMT2ACCNE1 | |
| SCHEMBL142445 | 0.80 | ALDH1A1 (0.47) | MAPK1L3MBTL1ALDH1A1KMT2ACCNE1 | |
| SCHEMBL5469498 | 0.80 | ALDH1A1 (0.47) | MAPK1L3MBTL1ALDH1A1KMT2AHPGD | |
| SCHEMBL1279658 | 0.79 | ALDH1A1 (0.46) | MAPK1L3MBTL1ALDH1A1KMT2ACCNE1 | |
| SCHEMBL7780925 | 0.79 | MAPK1 (0.47) | MAPK1L3MBTL1ALDH1A1KMT2AHPGD | |
| SCHEMBL2450503 | 0.79 | KMT2A (0.57) | MAPK1L3MBTL1ALDH1A1KMT2AHPGD | |
| SCHEMBL12417213 | 0.78 | GLA (0.40) | KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL15999210 | 0.78 | NOTUM (0.51) | MAPK1L3MBTL1ALDH1A1KMT2ACCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065152-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065152-A1 | PRODRUGS OF GUANFACINE | UGT1A6, GDA, UGT1A3 | MAPK1 4054/4885L3MBTL1 1342/4885ALDH1A1 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.