Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL406856 | 0.84 | MAPK1 (0.55) | KMT2AALDH1A1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL11323517 | 0.81 | ALDH1A1 (0.47) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL142445 | 0.81 | ALDH1A1 (0.47) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL1279658 | 0.80 | ALDH1A1 (0.46) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL7780925 | 0.80 | MAPK1 (0.47) | KMT2ATDP1MAPTALDH1A1HPGD | |
| SCHEMBL862827 | 0.80 | NR4A1 (0.57) | KMT2ASLC6A2SLC6A3LMNAMAPT | |
| SCHEMBL463692 | 0.79 | ESR1 (0.52) | KMT2ALMNAMAPTALDH1A1HPGD | |
| SCHEMBL10344103 | 0.78 | KMT2A (0.73) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL9696121 | 0.78 | KMT2A (0.73) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| Carbamic Acid SCHEMBL28871401 | 0.78 | CYP2C19 (0.44) | KMT2ATDP1SLC6A2SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065152-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065152-A1 | PRODRUGS OF GUANFACINE | UGT1A6, GDA, UGT1A3 | KMT2A 1095/4885TDP1 141/4885SLC6A2 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.