Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 4/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070576 | 0.90 | DHODH (0.45) | KCNQ3KCNQ2KCNE1KCNQ1MEN1 | |
| SCHEMBL4068770 | 0.88 | NPC1 (0.50) | MEN1KMT2ACYP11B2AHRDHODH | |
| SCHEMBL4063151 | 0.79 | P4HTM (0.43) | MEN1KMT2ATYK2ABL1SRC | |
| SCHEMBL4247327 | 0.77 | BRAF (0.45) | KCNQ3KCNQ2KCNE1KCNQ1MEN1 | |
| SCHEMBL4061473 | 0.74 | DHODH (0.49) | TYK2ABL1SRCDHODHRAB9A | |
| SCHEMBL4064010 | 0.73 | TYK2 (0.45) | KCNQ3KCNQ2KCNE1KCNQ1MEN1 | |
| SCHEMBL4058614 | 0.72 | GRM8 (0.53) | LMNAPOLB | |
| SCHEMBL4068973 | 0.72 | TYK2 (0.46) | KCNQ3KCNQ2KCNE1KCNQ1KMT2A | |
| SCHEMBL5934780 | 0.70 | P4HTM (0.53) | KCNQ3KCNQ2KCNE1KCNQ1MEN1 | |
| SCHEMBL4062046 | 0.70 | MAPT (0.54) | KCNQ3KCNQ2KCNE1KCNQ1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |